QRX 431
- Product Name
- QRX 431
- CAS No.
- 211110-63-3
- Chemical Name
- QRX 431
- Synonyms
- GC-1;EIEE3;NET44;QRX 431;Anti-GC1;Anti-OlfD;SobetiroMe;Anti-GW112;Anti-NET44;GC-1; QRX-431
- CBNumber
- CB22628338
- Molecular Formula
- C20H24O4
- Formula Weight
- 328.4
- MOL File
- 211110-63-3.mol
QRX 431 Property
- Melting point:
- 122 - 124°C
- Boiling point:
- 510.2±45.0 °C(Predicted)
- Density
- 1.152±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- 3.22±0.10(Predicted)
- form
- powder
- color
- white to beige
- InChIKey
- QNAZTOHXCZPOSA-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1900
- Product name
- Sobetirome
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- SML1900
- Product name
- Sobetirome
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $169.6
- Updated
- 2024/03/01
- Product number
- AV44041
- Product name
- Anti-SLC25A22 antibody produced in rabbit
- Purity
- IgG fraction of antiserum
- Packaging
- 100μL
- Price
- $443
- Updated
- 2024/03/01
- Product number
- 4554
- Product name
- GC1
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $196
- Updated
- 2021/12/16
- Product number
- 255368
- Product name
- GC 1
- Packaging
- 10mg
- Price
- $446
- Updated
- 2021/12/16
QRX 431 Chemical Properties,Usage,Production
Uses
GC 1 is a high affinity thyroid receptor α (TRα) and TRβ agonist.
Definition
ChEBI: Sobetirome is a diarylmethane.
Biological Activity
sobetirome (3,5-dimethyl-4[(4'-hydroxy-3'-isopropylbenzyl)-phenoxy] acetic acid, also known as gc-1 and qrx-431, is a member of a class of compounds known as selective thyromimetics.it was firstly developed by thomas scanlan’s group at the university of california-san francisco (ucsf) in 1995 1.in cholesterol-fed rats, sobetirome was shown to lower plasma cholesterol in a dose-dependent manner by up to 75% of untreated controls. in hypercholesterolemic mice, sobetirome was failed to induce ldl receptor mrna expression. in different mouse models, sobetirome and t-0681 were shown to promote bile acid production and biliary sterol secretion. in cynomolgus monkeys, sobetirome was shown to reduce plasma cholesterol in a dose-dependent manner by up to 30%. both sobetirome and t-0681 were shown to increase hepatic expression of the hdl receptor (scavenger receptor-bi, sr-bi) in animals.in phase i
Biochem/physiol Actions
Sobetirome is also termed as 2-(4-(4-(benzyloxy)-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid/ GC-1. It has an inner-ring and negatively charged carboxylate groups at physiological pH. Sobetirome is considered as a cholesterol lowering agent in humans.
storage
Store at -20°C
References
1. tancevski i, demetz e, eller p. sobetirome: a selective thyromimetic for the treatment of dyslipidemia. recent pat cardiovasc drug discov. 2011 jan;6(1):16-9.
QRX 431 Preparation Products And Raw materials
Raw materials
Preparation Products
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